What Is Metaglip (Glipizide-Metformin)? 

Metaglip is a medication that combines two different antidiabetic drugs, glipizide and metformin, in a single tablet. Glipizide belongs to the sulfonylurea class of drugs and helps stimulate insulin release from the pancreas, lowering blood sugar levels. Metformin, on the other hand, is a biguanide that reduces glucose production in the liver and improves the body’s response to insulin.

This combination medication is often prescribed to individuals with type 2 diabetes to achieve better blood sugar control. By targeting multiple aspects of glucose regulation, Metaglip aims to enhance the effectiveness of treatment and help patients manage their diabetes more effectively. It is crucial for individuals taking Metaglip to follow their healthcare provider’s instructions, monitor their blood sugar levels regularly, and be aware of potential side effects associated with the medication.

NDC Code is 0087-6081-31, 0087-6077-31, 0087-6078-31.

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Ingredients 

Metaglip contains two active ingredients: glipizide and metformin. In addition to the active ingredients, Metaglip tablets also contain various inactive ingredients, including but not limited to microcrystalline cellulose, povidone, magnesium stearate, and hypromellose. These inactive ingredients play a role in the medication’s formulation, stability, and overall characteristics. It’s essential for individuals using Metaglip to be aware of the complete list of ingredients and consult their healthcare provider if they have any allergies or concerns related to these components.

Who Can Take Metaglip (Glipizide-Metformin)?

Metaglip is typically prescribed for individuals with type 2 diabetes. Patients need to consult their healthcare provider to determine if Metaglip is a suitable treatment option for them. Generally, Metaglip may be recommended for individuals who:

  • Have type 2 diabetes: Metaglip is specifically designed for individuals with type 2 diabetes, which is a condition characterized by insulin resistance and impaired glucose regulation.
  • Require dual therapy: Metaglip is a combination medication that addresses different aspects of glucose control. It is often prescribed when treatment with a single medication is not sufficient to manage blood sugar levels.
  • Can tolerate both glipizide and metformin: Patients should be able to tolerate both glipizide and metformin individually, as they are the active ingredients in Metaglip. It’s important to discuss any potential allergies or sensitivities with the healthcare provider.
  • Are under the guidance of a healthcare professional: The use of Metaglip should be closely monitored by a healthcare provider who can adjust the dosage based on the individual’s response and overall health.

Dosage of Metaglip (Glipizide-Metformin)

The dosage of Metaglip (glipizide-metformin) can vary based on individual factors such as the severity of diabetes, overall health, and response to the medication. 

Metaglip is available in different strengths, typically combining a specific amount of glipizide with a specific amount of metformin in each tablet. Common dosage strengths include combinations like 2.5 mg/250 mg, 2.5 mg/500 mg, 5 mg/500 mg, and others.

Patients are usually advised to take Metaglip with meals to reduce the risk of gastrointestinal side effects associated with metformin. Regular monitoring of blood sugar levels is essential, and healthcare providers may adjust the dosage based on the individual’s response.

It’s crucial to attend regular follow-up appointments with the healthcare provider to assess the effectiveness of the treatment and address any potential side effects or concerns. As with any medication, adherence to the prescribed dosage and instructions is vital to achieving optimal results and managing diabetes effectively.

Important Safety Information 

Glipizide, one of the components of Metaglip, can cause low blood sugar (hypoglycemia). Patients should be cautious about symptoms such as shakiness, sweating, rapid heartbeat, confusion, or dizziness and seek immediate medical attention if these occur.

Metformin, the other component, may rarely cause a severe condition called lactic acidosis. This risk increases with conditions such as kidney impairment or severe liver disease. Patients should promptly report unusual symptoms like muscle pain, difficulty breathing, or stomach discomfort.

Metaglip can affect kidney function, so informing the healthcare provider of any existing kidney issues is crucial. Regular kidney function tests may be recommended.

Individuals with liver disease should exercise caution, as both glipizide and metformin can affect liver function. Liver function tests may be conducted regularly.

Inform the healthcare provider about any allergies to sulfa drugs or other medications. Metaglip contains sulfonamide, which may cause allergic reactions in some individuals.

Excessive alcohol consumption can potentiate the risk of lactic acidosis and should be limited or avoided while taking Metaglip.

Pregnant or breastfeeding individuals should consult their healthcare provider before using Metaglip, as its safety in these situations may not be well-established.

It’s essential to inform healthcare providers about Metaglip use before undergoing surgery or any medical procedures, as temporary discontinuation may be necessary.

Individual responses to medication can vary, so open communication with the healthcare team is crucial for safe and effective diabetes management.

Contraindications

Metaglip (glipizide-metformin) has contraindications, meaning there are certain conditions or situations in which its use is not recommended. Contraindications for Metaglip include:

  1. Hypersensitivity to Sulfonylureas or Metformin: Individuals allergic or hypersensitive to sulfonylureas (such as glipizide) or metformin should not take Metaglip.
  2. Renal Impairment: Metaglip is contraindicated in patients with significant renal impairment, as metformin can affect kidney function. Kidney function should be assessed before initiating treatment and monitored regularly.
  3. Hepatic Impairment: Individuals with severe hepatic impairment should avoid Metaglip, as both glipizide and metformin can affect liver function.
  4. Metabolic Acidosis: Metaglip is contraindicated in patients with metabolic acidosis, including diabetic ketoacidosis. If metabolic acidosis is suspected, treatment should be discontinued.
  5. Cardiovascular Collapse: Metaglip is contraindicated in cases of cardiovascular collapse or shock.
  6. Surgery and Radiological Procedures: Metaglip should be temporarily discontinued in patients undergoing surgery or radiological procedures involving intravascular administration of iodinated contrast materials, as this can increase the risk of lactic acidosis.

Individuals with these contraindications should discuss alternative treatment options with their healthcare provider. 

Interactions

Metaglip (glipizide-metformin) may interact with other medications, substances, or medical conditions. Individuals must inform their healthcare provider about all the medications, supplements, and over-the-counter drugs they take. Some potential interactions include:

  1. Other Antidiabetic Medications: Concurrent use of other antidiabetic medications may increase the risk of hypoglycemia. The dosage of Metaglip or other antidiabetic drugs may need adjustment to avoid low blood sugar levels.
  2. Diuretics (Water Pills): Diuretics may enhance the effects of Metaglip and increase the risk of dehydration and electrolyte imbalances.
  3. NSAIDs (Nonsteroidal Anti-Inflammatory Drugs): NSAIDs, such as ibuprofen or naproxen, may increase the risk of lactic acidosis when used with metformin.
  4. Beta-Blockers: Some beta-blockers can mask the symptoms of hypoglycemia (low blood sugar) and may affect glucose metabolism.
  5. Alcohol: Excessive alcohol consumption can potentiate the risk of lactic acidosis and should be limited or avoided.
  6. Cimetidine: Cimetidine, a medication used for stomach ulcers, may increase the concentration of glipizide in the blood.
  7. Certain Antibiotics: Some antibiotics, such as trimethoprim/sulfamethoxazole, may potentiate the effects of sulfonylureas, including glipizide.
  8. Iodinated Contrast Materials: Metaglip should be temporarily discontinued before specific radiological procedures involving intravascular administration of iodinated contrast materials.

This is not a complete list; interactions can vary based on individual health and medications. Healthcare providers will consider these factors and adjust the treatment plan accordingly. Communicating openly with the healthcare team and following their recommendations is crucial to ensure safe and effective diabetes management.

Side Effects

Metaglip (glipizide-metformin) may cause side effects, and individuals should be aware of potential adverse reactions. Common side effects may include:

  1. Hypoglycemia: Low blood sugar levels (hypoglycemia) can occur, especially if the medication is not taken with or around meals. Symptoms may include shakiness, sweating, rapid heartbeat, confusion, or dizziness.
  2. Gastrointestinal Issues: Metformin can cause gastrointestinal side effects such as nausea, vomiting, diarrhea, and abdominal discomfort. These symptoms may improve with time or if the medication is taken with meals.
  3. Weight Gain: Some individuals may experience weight gain while taking Metaglip.
  4. Lactic Acidosis: Although rare, metformin can potentially lead to a serious condition called lactic acidosis. Symptoms include muscle pain, difficulty breathing, and stomach discomfort. This requires immediate medical attention.
  5. Allergic Reactions: Allergic reactions to sulfonylureas or metformin may occur, presenting as rash, itching, swelling, severe dizziness, or difficulty breathing. Seek medical attention if these symptoms occur.
  6. Liver Function Changes: Metaglip can affect liver function, and in rare cases, it may lead to liver problems. Monitoring of liver function may be necessary.
  7. Photosensitivity: Some individuals may experience increased sensitivity to sunlight (photosensitivity) while taking sulfonylureas.

It’s important to note that not everyone will experience these side effects, and some individuals may tolerate Metaglip well. Individuals should promptly report any unusual or severe symptoms to their healthcare provider. 

Overdose

Overdosing on Metaglip (glipizide-metformin) can lead to severe complications and requires immediate medical attention. Symptoms of an overdose may include:

Excessive intake of Metaglip can lead to a drop in blood sugar levels, resulting in symptoms such as confusion, shakiness, sweating, rapid heartbeat, and, in severe cases, loss of consciousness or seizures.

In rare cases, an overdose of metformin can contribute to lactic acidosis, a potentially life-threatening condition characterized by symptoms such as muscle pain, difficulty breathing, abdominal discomfort, and lethargy.

If an overdose is suspected, it’s crucial to seek emergency medical attention immediately. Treatment may involve supportive measures to stabilize blood sugar levels and address potential complications. The healthcare provider may administer glucose or intravenous fluids to counteract hypoglycemia and monitor the individual closely.

Preventing overdose involves strict adherence to the prescribed dosage and instructions provided by the healthcare provider. If a dose is missed, it’s important not to double the next dose but to follow the healthcare provider’s guidance on how to proceed.

Individuals should store Metaglip securely, away from children and pets, and should not share their medication with others. Open communication with the healthcare team is essential to ensure the safe and effective use of Metaglip and to address any concerns or questions about the medication.

Storage

Store Metaglip at room temperature, away from extremes of heat and cold. Avoid exposure to temperatures above 86°F (30°C).

Keep the medication in a dry place. Avoid storing it in bathrooms or other humid environments.

Protect Metaglip from direct sunlight and excessive light exposure. It’s typically recommended to store medications in their original packaging to shield them from light.

Ensure the medication is stored in a childproof container, out of the reach of children and pets. If Metaglip comes in blister packs or sealed containers, keep it sealed until the time of use.

Check the expiration date on the medication packaging, and do not use Metaglip if it has expired.

Follow any specific storage instructions provided by the healthcare provider or pharmacist.

It’s important to note that these are general guidelines, and individuals should always refer to the specific storage instructions provided with their medication. If there are any doubts or concerns about the storage of Metaglip, it’s advisable to consult with the healthcare provider or pharmacist for clarification. Proper storage helps maintain the effectiveness and safety of the medication.

Drugs Similar to Metaglip (Glipizide-Metformin) 

Metaglip is a combination medication that contains two active ingredients: glipizide and metformin. Each of these components belongs to different classes of antidiabetic drugs. If you’re looking for drugs similar to Metaglip or its generic alternatives, it’s helpful to consider the individual components:

  1. Glipizide (Sulfonylurea): Examples include glyburide, glimepiride, and chlorpropamide. These medications stimulate insulin release from the pancreas.
  2. Metformin (Biguanide): Metformin is available as a standalone medication and is commonly prescribed under various brand names or as a generic. Some examples include Glucophage, Fortamet, and Riomet.

If someone is prescribed Metaglip and has concerns about its cost or availability, discussing these concerns with their healthcare provider can be helpful. The healthcare provider can explore alternative medications based on individual health needs and considerations.

It’s important to note that while these medications share similar mechanisms of action, they may differ in side effects, dosages, and specific indications. 

FAQ 

How does Metaglip work?

Glipizide stimulates insulin release from the pancreas, and metformin reduces glucose production in the liver and improves insulin sensitivity, working together to regulate blood sugar levels.

Can Metaglip cause weight gain?

Some individuals may experience weight gain while taking Metaglip. It’s important to discuss any concerns about weight changes with the healthcare provider.

Is Metaglip suitable for all types of diabetes?

Metaglip is specifically designed for individuals with type 2 diabetes. It is not intended for the treatment of type 1 diabetes.

Can Metaglip be taken during pregnancy?

Pregnant individuals should consult their healthcare provider before using Metaglip, as the safety of the medication during pregnancy is not well-established.

Does Metaglip interact with alcohol?

Excessive alcohol consumption can increase the risk of lactic acidosis, so it’s advisable to limit or avoid alcohol while taking Metaglip.

What should I do if I miss a dose of Metaglip?

If a dose is missed, it’s important not to double the next dose. Instead, follow the healthcare provider’s instructions on how to proceed with the medication schedule.

Can older people use Metaglip?

Metaglip can be prescribed for elderly individuals, but the healthcare provider will consider factors such as renal function and overall health to determine the appropriate dosage. Regular monitoring is essential.

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